Veterinary Pharmacology & Toxicology
The Department of Veterinary Pharmacology was established in 1969 along with the inception of the College of Veterinary Science. Department imparts teaching, research and extension activities in the disciplines of Pharmacology and Toxicology. Diagnostic services are offered to livestock owners, farmers and veterinarians related to toxicity cases. Adequate facilities for the award of B.V.Sc. & A.H., M.V.Sc. and Ph.D degrees are available in the Department of Veterinary Pharmacology & Toxicology. In addition, the department is also involved in various refresher courses pertaining to training of veterinary officers and farmers.
Collaborative Research Centre for Veterinary Ayurveda
The Collaborative Research Centre for Veterinary Ayurveda (CRCVA) has beenestablished at the Department of Veterinary Pharmacology and Toxicology, GuruAngad Dev Veterinary and Animal Sciences University (GADVASU), Ludhiana, Punjabthrough a memorandum of understanding (MoU) between the Central Council forResearch in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, Government of India,New Delhi and Guru Angad Dev Veterinary and Animal Sciences University(GADVASU), Ludhiana, Punjab in 2016. This is the first and only of its kind centre in India to promoteresearch in new and upcoming branch of veterinary Ayurveda.The core objectives of this centre are:
- To explore and revive ancient manuscripts/ rare books on Veterinary Ayurveda
- Documentation and publication of traditional practices and local health tradition in Veterinary Ayurveda
- Scientific validation of both textual and traditional practices including development of new formulation.
Goals
- Toxicity of agrochemicals in livestock
- Mineral toxicity in livestock
- Pharmacological studies of therapeutic agents
- Therapeutic and toxic potential of indigenous plants
- To study pesticide-induced endocrine disruption.
- To evaluate effects of pesticide and mineral interaction on animals.
- To undertake studies on pharmacokinetics and pharmacodynamics of newly introduced therapeutic agents.
- To correlate pesticide-induced adverse effects with animal health and production.
- To analyze the impact of pesticide and mineral interaction on health disorders in animals.
- PK-PD modelling of therapeutic agents in animals.
- To identify indigenous plants having therapeutic potential and evaluate their medicinal values to promote use of herbal preparations in organic livestock farming.
- Therapeutic drug monitoring.
- In-vitro toxicological studies of xenobiotics
- Genotoxicity studies of environmental pollutants
Vision
Short term goals
Long term goals
Thrust Area
- Strategies for prevention of antimicrobial resistance in livestock.
- Clinical Pharmacology
- Therapeutic potential of indigenous plants of Punjab.
- Xenobiotic induced endocrine disruption.
Veterinary Pharmacology & Toxicology
Dr. Swaran Singh Randhawa
Address : Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana
Email:drswaran68@gmail.com, vpthod@gmail.com
Call: +91-161-2414032 (O)
Brief Introduction :
Dr. Swaran Singh Randhawa, has joined as Dean, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana. also holds the charge of head Department of Veterinary Pharmacology and Toxicology. Dr. Swaran Singh Randhawa is a devoted and industrious clinician,teacher as well as a researcher. He has an excellent scientific career, evidenced by his quality research and clinical papers. He has published more than 70 research papers in national and international journals. He has been honored with University Best Teacher Award for the year 2017-18. He did a pioneer work on ‘Bovine lameness’. For the first time in India, He evaluated sole thickness using ultrasonography in crossbred dairy cattle, which can be used as a selection criterion for breeding programs. He developed Hindi version of “Claw Health Atlas” for International Committee for Animal Recording (ICAR). He also standardized ‘Fast localized abdominal ultrasonography of horses’ (FLASH) for diagnosis in equine colic patients. Recently, he standardized transtracheal wash (TTW) and bronchoalveolar lavage (BAL) techniques for diagnosis in respiratory problems in equines. He also established endoscopy for diagnosis of upper respiratory tract (URT) diseases of equines at the university hospital. His research has been acclaimed nationally and internationally (Finland and New Zealand) with more than 70 presentations in conferences. Presently, He is part of DBT Canine Research Centre and working on the project ‘Elucidating the etiology of chronic gastro-enteropathies in dogs’. He guided 10 postgraduate students. He is currently supervising 2 M.V.Sc and 2 Ph.D student. Presently, he is Editor of Indian Journal of Veterinary Medicine and member of the National Academy of Veterinary Sciences (India).
Faculty Detail
Dr. Simrat Pal Singh Saini
Designation : Professor
Contact Address : Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab 141004
Telephone : 0161-2414032
Mobile : 9876198402
Email : spalsaini@yahoo.com
Academic Credentials
- B.V.Sc. & A.H.
- M.V.Sc.
- Ph. D.
- Post-doctoral Fellow University of Pittsburgh, PA, USA
Teaching appointments
- Teaching at B.V.Sc & A.H., M.V.Sc. and Ph.D. levels
Other appointments
- University NRI Advisor
Area of research
- Drug metabolism and pharmacokinetics (DMPK) in clinical cases
- Toxicology in animal disease models, involving multi-disciplinary, cross-functional teams
Ongoing projects
|
S.no. |
PI/Co.PI |
Title of the project |
Funding Agency |
Period |
|
1 |
PI |
Ameliorative measures for
enrofloxacin-induced testicular toxicity in rats. |
UGC, New Delhi
|
2014 |
Research honours awards
- Post-doctoral Fellowship by University of Pittsburgh, Pittsburgh, PA.
- Limbach Entrepreneurial Center Scholarship by University of Pittsburgh, PA
- Young Scientist Award by Indian Society of Pharmacology and Toxicology, New Delhi.
- Post-doctoral Fellowship by CSIR, New Delhi.
- Senior Research Fellowship in Doctoral program by CSIR, New Delhi.
- University merit scholarship in Master’s program.
- State fellowship in Bachelor’s program.
- University PIO (Public Information Officer)
- University Ombudsperson
- Incharge IVSA ( International Veterinary Students Association)
- Member, IAEC (Institutional Animal Ethics Committee
No of publications
|
Publication
- Bhardwaj P, Sidhu PK, Saini SPS, M B D, Rampal S. 2019. Pharmacokinetic-pharmacodynamic relationship of marbofloxacin for Escherichia coli and Pasturella multocida following repeated intramuscular administration in goats. J Vet Pharmacol Ther.Jul;42(4):430-439. doi: 10.1111/jvp.12776. Epub 2019 May 7.PMID: 31102281
- Xie W, Uppal H, Saini SP, Mu Y, Little JM, Radominska-Pandya A, Zemaitis MA. 2004 Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Drug Discov Today.May 15;9(10):442-9. doi: 10.1016/S1359-6446(04)03061-2.PMID: 15109949 Review.
- Singh NK, Saini SPS, Singh H, Jyoti, Sharma SK, Rath SS 2017 In vitro assessment of the acaricidal activity of Piper longum, Piper nigrum, and Zingiber officinale extracts against Hyalomma anatolicum ticks. .Exp Appl Acarol.Mar;71(3):303-317. doi: 10.1007/s10493-017-0113-2. Epub 2017 Mar 1.PMID: 28251408
- Saini SP, Zhang B, Niu Y, Jiang M, Gao J, Zhai Y, Hoon Lee J, Uppal H, Tian H, Tortorici MA, Poloyac SM, Qin W, Venkataramanan R, Xie W. 2011Hepatology Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice.. Dec;54(6):2208-17. doi: 10.1002/hep.24646.PMID: 21898498
- Gaur A, Saini SP, Garg SK, Chaudhary RK, Srivastava AK. 2004 Pharmacokinetics of ofloxacin after a single intravenous bolus dose in neonatal calves. J Vet Pharmacol Ther. Apr;27(2):115-7. doi: 10.1111/j.1365-2885.2004.00493.x.PMID: 15096110
- Uppal H, Saini SP, Moschetta A, Mu Y, Zhou J, Gong H, Zhai Y, Ren S, Michalopoulos GK, Mangelsdorf DJ, Xie W. 2007 Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology.Feb;45(2):422-32. doi: 10.1002/hep.21494.PMID: 17256725
- Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, Ren S, Moore DD, Evans RM, Xie W. 2004 A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol.Feb;65(2):292-300. doi: 10.1124/mol.65.2.292.PMID: 14742670
- Saini SP, Mu Y, Gong H, Toma D, Uppal H, Ren S, Li S, Poloyac SM, Xie W.. 2005 Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice. Hepatology. Mar;41(3):497-505. doi: 10.1002/hep.20570.PMID: 15726644
- Uppal H, Toma D, Saini SP, Ren S, Jones TJ, Xie W. 2005 Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. Hepatology.Jan;41(1):168-76. doi: 10.1002/hep.20512.PMID: 15619241
- Mu Y, Stephenson CR, Kendall C, Saini SP, Toma D, Ren S, Cai H, Strom SC, Day BW, Wipf P, Xie W. 2005 A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development. Mol Pharmacol. Aug;68(2):403-13. doi: 10.1124/mol.105.013292. Epub 2005 May .PMID: 15872116
- Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, Evans RM. 2003 Proc Natl Acad Sci U S A. Apr 1;100(7):4150-5. doi: 10.1073/pnas.0438010100. Epub 2003 Mar 18.PMID: 12644700
- Gong H, Singh SV, Singh SP, Mu Y, Lee JH, Saini SP, Toma D, Ren S, Kagan VE, Day BW, Zimniak P, Xie W. 2006 Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol. Feb;20(2):279-90. doi: 10.1210/me.2005-0205. Epub 2005 Sep 29.PMID: 16195250
- Gaur A, Garg SK, Saini SP. 2005 Comparative disposition kinetics of ofloxacin following a single i.m. and s.c. administration in neonatal calves. J Vet Pharmacol Ther.Oct;28(5):485-8. doi: 10.1111/j.1365 -2885. 00687.x.PMID: 16207313
- Saini SP, Srivastava AK. 2001 The disposition kinetics, urinary excretion and dosage regimen of ciprofloxacin in buffalo calves (Bubalus bubalis). Vet Res Commun. Dec;25(8):641-9. doi: 10.1023/a:1012791113342.PMID: 11767010
- Saini SP, Srivastava AK. The disposition kinetics, urinary excretion and dosage regimen of amikacin in cross-bred bovine calves. Vet Res Commun. 1998 Jan;22(1):59-65. doi:10.1023/a:1005987212046.PMID: 954199
Veterinary Pharmacology & Toxicology
Former Faculty
| Sr. No. | Name | Designation | Superannuation/ Transfer/ Promotion | Photograph |
|---|---|---|---|---|
| 1. | Dr. R.K. Chaudhary | Professor | 10-06-2011(Took VSR) | |
| 2. | Dr. Pritam Kaur Sidhu | Senior Toxicologist | 27-06-2016(Took VSR) | |
| 3. | Dr. H.S.Sandhu | Professor | Expired on 17-11-2016 |  |
| 4. | Dr. S. Rampal | Professor | 31.10.2023 |
Veterinary Pharmacology & Toxicology
|
Sr. no |
Title of the Project |
Objectives |
Investigators |
Budget |
Sponsoring Agency (Rs.) |
Duration of the Project |
|---|---|---|---|---|---|---|
|
1. |
NPV-56: Toxicity Studies on Insecticides in Livestock
|
· To study toxicity pattern in different species of livestock following administration of commonly used insecticides in different doses and by administration by different safe concentration and dose in use. · To study various biochemical parameters in order to evolve suitable diagnostic methods for poisoning resulting from different groups of insecticides. · Working on the treatment in poisoning with different groups of insecticides so as to evolve effective antidotal treatment in such poisoning.
|
Dr. S. K. Sharma Rashmi Sagar Bhullar |
Salary component |
Pb. Govt |
Ongoing |
|
2. |
Collaborative Research centre for Veterinary Ayurveda (CRCVA) |
· To explore and revive ancient manuscript /rare books on Veterinary Ayurveda. · Documentation and publication of traditional practice and local health tradition in Veterinary Ayurveda · Scientific validation of both textual and traditional practices including development of new formulation. |
Drs. S.K Sharma(Incharge) Santosh Mane and Amit Ashok |
CCRAS, Ministry of AYUSH has appointed two research officers and granted four research projects
|
CCRAS, Ministry of Ayush |
2016- 2021 5years |
|
3. |
Development of Nursery for cultivation of selected medicinal plants at Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab |
· Cultivation of selected plant species at proposed plant nursery. · Distribution of these plant specimens among farmers, cattle breeders and even common people at reasonable cost. · Sensitization of farmers about traditional medicinal practices |
Drs. S Mane, SK Sharma, V.K. Dumka, MS Bal |
Rs 5.40 Lacs |
National medicinal Plant Board, Ministry of Ayush |
2019-2024 5 years |
|
4 |
Evaluation of Clinical efficacy of “AYUSH V-24” (a coded Ayurvedic formulation) in the Management of selected gastro intestinal illness in Ruminants |
· To evaluate the clinical efficacy of AYUSH-V-24 in the Management of selected Gastro Intestinal illness in Ruminant. · A comprehensive study of AYUSH -V-24 in line with Ayurvedic principle. · A drug safety evaluation of “AYUSH-V-24” formulation in ruminants.
|
Drs. Santosh Mane, Amit Ashok, M.K. Lonare, V.K. Dumka, |
Rs. 39,44,160 lacs |
CCRAS, Ministry of Ayush |
2019- 2022 3 years |
|
5 |
Clinical evaluation of efficacy of Ayurvedic formulation for augmentation of milk production in ruminants |
· Clinical evaluation of efficacy of Ayurvedic formulation for augmentation of milk production in ruminants. · A drug safety appraisal of “Ayurvedic formulation” in ruminants · A critical study of “Ayurvedic formulation” in line with Ayurvedic Principle.
|
Drs. Saloni Singla, Santosh Mane, V.K. Dumka, M.K. Lonare, Mandeep Singla |
Rs.33,50,160 lacs |
CCRAS, Ministry of Ayush |
2019- 2022 3 years |
|
6 |
Clinical evaluation of the efficacy of Padmakanta Yoga, an Ayurveda formulation in the management of Mastitis in bovines. |
· To evaluate the efficacy of Padmakanta Lepa and Kwatha formulation in the treatment of subclinical & fibrotic cases of mastitis in bovines. · A comprehensive study for Padmakanta Lepa and Kwatha formulation in the treatment of mastitis in line with Ayurveda principle.
|
Drs Amit A, Rashmi Sagar Santosh S. Mane,V.K. Dumka,D.K Gupta |
28,55,600 lacs |
CCRAS, Ministry of Ayush |
2021- 2024 3 years |
Veterinary Pharmacology & Toxicology
- Antibacterial efficacy of various therapeutic agents in disease models and clinical conditions have been established in indigenous animals, especially in buffalo species.
- Development and evaluation of drug loaded Nano-particles.
- Therapeutic and commercial potential of various indigenous drugs has been established.
- Preventive and therapeutic measures for mineral toxicities have been worked out for selenium, fluoride, molybdenum, arsenic and lead in livestock.
- Management and therapeutic strategies for insecticide poisoning have been standardized in bovines.
Veterinary Pharmacology & Toxicology
- Testing of toxicity related samples.
- Refresher courses for veterinary officers.
- Specialized dairy training course for farmers.
- TV/Radio talks.
- Pashu Palan Melas and other exhibitions
Veterinary Pharmacology & Toxicology
| Research | : | 243 |
| Extension | : | 45 |
| Books/Mannuals | : | 5/6 |
Veterinary Pharmacology & Toxicology
Laboratories
- Ethnopharmacology
- Toxicology
- Clinical Pharmacology
- Pharmacy
- Cell culture
Equipment
- High Pressure Liquid Chromatography
- Gas Chromatography
- Chemiluminiscence
- Analgesimeter
- Convulsiometer
- UV Spectrophometer
- Inverted & Fluorescence Microscope
- Ultra-sonicator
- Elevated plus-maze
- ELISA reader
- Autoanalyzer
- Closed cell concentrator
- Cold centrifuge
- Solid phase extraction
- Deep freezers
- Spectrophotometers
- BOD incubator
- Water ultrafiltration unit
- Lypholizer
Veterinary Pharmacology & Toxicology
- The Department has organized five conferences, two winter schools and several seminars.
- The faculty has been bestowed with several national and international awards including young scientist awards, best paper awards and gold medals in various conferences.